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. Author manuscript; available in PMC: 2019 May 15.
Published in final edited form as: J Immunol. 2018 Apr 2;200(10):3556–3567. doi: 10.4049/jimmunol.1701504

Figure 9. Inflammasome independent lipidosome activation by CS.

Figure 9

Cells take up silica by phagocytosis. Early during phagosome maturation process lipidosome is activated in the cytosol as the primary source of CS-induced LTB4 production. Enzymes required for LTB4 production as well as Rab40c are essential structural components of the CS-induced lipidosome. Inflammasome activation and IL-1β production requires the phagosome fusion with lysosomes. JNK activation is required for both LTB4 and IL-1β production.