Table 3.

Pairwise analyses of associations between dropout rate and phenotypes or genotypes for genes most significantly associated with dropout rate in prior analysis. PM = poor metabolizer; IM = intermediate metabolizer; EM = extensive metabolizer; S = short allele; L = long allele; OR = Odds Ratio, CI = Confidence Intervals. Higher odds ratios indicate a higher likelihood of a patient dropping out of treatment.

		Both Medications (n = 764)		Methadone (n = 354)		Buprenorphine (n = 410)
Gene	Comparison	p-value	OR (95% CI)	p-value	OR (95% CI)	p-value	OR (95% CI)
CYP3A4	EM vs IM+PM	0.085	1.95 (0.91 – 4.19)	0.427	1.66 (0.48 – 5.77)	0.147	2.06 (0.78 – 5.44)
COMT (rs4680)	G/G vs A/G	0.192	1.32 (0.87 – 2)	0.713	1.14 (0.56 – 2.34)	0.300	1.32 (0.78 – 2.23)
	G/G vs A/A	0.031	1.82 (1.06 – 3.15)	0.037	3.16 (1.07 – 9.31)	0.377	1.34 (0.7 – 2.58)
	A/G vs A/A	0.223	1.38 (0.82 – 2.32)	0.051	2.76 (0.99 – 7.68)	0.959	1.02 (0.54 – 1.9)
SLC6A4 (5- HTTLPR)	L/S vs L/L	0.168	0.74 (0.48 – 1.14)	0.503	0.77 (0.36 – 1.65)	0.287	0.75 (0.44 – 1.27)
	L/S vs S/S	0.008	0.52 (0.32 – 0.84)	0.029	0.41 (0.19 – 0.91)	0.121	0.61 (0.33 – 1.14)
	L/L vs S/S	0.161	0.7 (0.43 – 1.15)	0.143	0.54 (0.23 – 1.23)	0.533	0.82 (0.44 – 1.53)
HTR2A (rs6311)	A/A vs A/G	0.029	0.57 (0.35 – 0.94)	0.213	0.58 (0.25 – 1.36)	0.083	0.57 (0.3 – 1.08)
	A/G vs G/G	0.196	0.76 (0.5 – 1.15)	0.404	0.73 (0.35 – 1.52)	0.608	0.87 (0.51 – 1.48)
	A/A vs G/G	0.291	1.32 (0.79 – 2.23)	0.621	1.26 (0.51 – 3.09)	0.204	1.53 (0.79 – 2.96)