Fig. 4. Altered character of Hox mutant medullary stroma.
LEF1 (green) labels the early nephron segments, podocytes, and medullary stromal cells surrounding the forming collecting ducts, while P57 labels podocytes (arrow heads) and medullary stroma. Asterisks highlight cortical differentiating nephron segments. X labels a central medullary collecting duct. Note that in mutants the medullary stroma is present, and continues to label with LEF1, but does not label with P57 (arrows).