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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: J Mol Cell Cardiol. 2018 Mar 7;118:26–35. doi: 10.1016/j.yjmcc.2018.03.003

Figure 3.

Figure 3

Schematic outline of the involvement of necroptosis in elimination of cells of the cardiovascular system and reported inhibition strategies based on necroptosis pathway. A) Role of Nec1s in treatment of atherosclerosis in response to inflammation and necroptotic death of cells including macrophages and VSMCs. B) Ischemia-reperfusion related injury has been found to eliminate cardiomyocytes, notably via necroptotic machinery somewhat different from the conventional signaling pathway. C) Treatment of abdominal aortic aneurysms by Nec1s and potentially NSA by prevention of VSMC-necroptosis as a therapeutic strategy. ApoE−/−, apolipoprotein E knockout; Ldlr−/−, low-density lipoprotein receptor knockout; Mφ, macrophage; I/R, ischemia reperfusion; mPTP, mitochondrial permeability transition pore