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L-Tyrosine adjuvant activity does not require inflammasome activation. A) No difference in T cell responses between wild-type and ASC KO groups was found, regardless of vaccine formulations. B) L-Tyrosine adjuvant activity requires peptide co-precipitation. Mice received 8×105 pmel-1 T cells and indicated treatments on day 0. n= 5 mice per group. Data are representative of 3 independent experiments. WT: wild type, ASC KO: ASC knockout.
