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. Author manuscript; available in PMC: 2019 May 15.
Published in final edited form as: J Immunol. 2018 Apr 9;200(10):3353–3363. doi: 10.4049/jimmunol.1701652

Figure 4. NOD.HLA-B*39:06Hom.β2mKO mice are susceptible to T1D.

Figure 4

(A) The results of diabetes incidence studies performed at The Jackson Laboratory using female NOD.HLA-B*39:06Hom.β2mKO and NOD.HLA-A*02:01.β2mKO mice are shown (p = 0.17, Mantel-Cox). (B) Female non-diabetic NOD.HLA-A*02:01.β2mKO (n = 16) and NOD.HLA-B*39:06Hom.β2mKO mice (n = 16) were euthanized at 40 wks and mean insulitis scores determined as described in Materials and Methods. Each circle represents an individual mouse. Lines represent mean ± SEM (p = 0.15, Mann-Whitney). Representative islets with their assigned scores for the female non-diabetic NOD.HLA-A*02:01.β2mKO (C) and NOD.HLA-B*39:06Hom.β2mKO mice (D) are shown. Scale bar represents 100 µm.