Skip to main content
. Author manuscript; available in PMC: 2019 May 15.
Published in final edited form as: J Immunol. 2018 Apr 9;200(10):3353–3363. doi: 10.4049/jimmunol.1701652

Figure 7. Class I HLA transgene identity dramatically alters TCR Vβ usage among CD8 T cells, but thymic insulin expression does not.

Figure 7

Splenocytes from three female mice per group were analyzed by flow cytometry for TCR Vβ usage. (A) CD8 T cells, (B) CD4 T cells, and (C) CD4+CD25+ T cells were considered separately. Graphs depict mean + SEM; p values are indicated (t test). Significant differences between NOD.HLA-B*39:06.β2mKO and NOD.HLA-A*02:01.β2mKO mice are indicated with p values, as are those between NOD.HLA-B*39:06.β2mKO and NOD.HLA-B*39:06.β2mKO.Ins2KO mice.