Table 2. Baseline Human Subject Data.
, Baseline data for subjects in NaHCO3 and NaCl treatment groups is given in Table 2. Data represent values obtained on the first day of the protocol following overnight fasting and prior to subjects ingesting either NaHCO3 or NaCl solutions. Data are expressed as mean±SE. Data are compared by unpaired students t-test. P<0.05 was treated as significant.
| Baseline data | |||
|---|---|---|---|
| Variable | Control subjects (NaCl) n=6 | Treatment subjects (NaHCO3) n=12 | P (students t-test) |
| Age (years) | 24.8±1.2 | 27.4±2.0 | N.S |
| Height (cm) | 177.0±3.1 | 167.7±3.2 | N.S |
| Weight (kg) | 81.0±7.8 | 71.9±5.3 | N.S |
| BMI(kg/m2) | 25.7±2.1 | 25.3±1.2 | N.S |
| Systolic blood pressure (mmHg) | 118.7±4.7 | 118.6±3.4 | N.S |
| Diastolic blood pressure (mmHg) | 71.8±3.2 | 68.3±2.7 | N.S |
| CRP | 1.06±0.30 | 1.22±0.58 | N.S |
| Hct (%) | 45±1 | 43±2 | N.S |
| Glucose (mg/dL) | 92±4 | 90±2 | N.S |
| BUN (mg/dL) | 12.5±1.0 | 13.3±1.2 | N.S |
| Creatinine (mg/dL) | 0.84±0.06 | 0.85±0.07 | N.S |
| Na (mM) | 141±1 | 140±1 | N.S |
| K (mM) | 4.0±0.1 | 4.3±0.1 | N.S |
| Cl (mM) | 100±1 | 101±1 | N.S |
| CO2 (mM) | 21±0 | 21±1 | N.S |
| Protein (g/dL) | 6.9±0.1 | 6.9±0.1 | N.S |
| Albumin (g/dL) | 4.5±0.1 | 4.4±0.1 | N.S |
| TNFα+ neutrophils (% blood leukocytes) | 55±2.2 | 26±7.3 | 0.0003** |
| M1 macrophages (% blood leukocytes) | 3.3±0.3 | 1.6±0.5 | 0.007** |
| M2 macrophages (% blood leukocytes) | 1.9±0.2 | 1.4±0.2 | N.S |