Table 1.

Summary of MRI lesion severity scores.

Time Post DFP (h)	6*		12**		18*		24**		48*		72***
	Incidence	Severity	Incidence	Severity	Incidence	Severity	Incidence	Severity	Incidence	Severity	Incidence	Severity
Hippocampus	0/6	n/a	4/6	0.6 ± 0.4	4/6	0.2 ± 0.0	5/6	0.7 ± 0.5	5/5	0.9 ± 0.7	11/11	1.5 ± 0.8
Piriform Cortex	4/6	0.2 ± 0.0	6/6	1.2 ± 0.5	3/6	1.1 ± 1.0	6/6	2.3 ± 0.8	5/5	1.8 ± 0.6	10/11	1.9 ± 0.9
Thalamus	6/6	1.0 ± 0.5	6/6	2.6 ± 0.3	5/6	1.1 ± 0.7	6/6	2.2 ± 0.6	5/5	0.9 ± 0.8	10/11	0.8 ± 0.5
Cerebral Cortex	6/6	0.5 ± 0.6	6/6	1.2 ± 1.0	6/6	1.7 ± 0.9	5/6	1.4 ± 1.0	5/5	0.9 ± 0.6	7/11	1.2 ± 0.7
Substantia Nigra	3/6	1.4 ± 0.8	1/6	0.2 (n=1)	3/6	1.5 ± 0.9	1/6	0.2 (n=1)	1/5	1.2 (n=1)	2/11	0.7 ± 0.7
Caudate Putamen	0/6	n/a	1/6	0.2 (n=1)	5/6	1.0 ± 0.8	2/6	0.2 ± 0.0	3/5	0.7 ± 0.4	2/11	0.6 ± 0.5
Lateral Ventricles	0/6	n/a	6/6	0.5 ± 0.2	2/6	0.6 ± 0.5	5/6	1.1 ± 0.4	0/5	n/a	5/11	1.3 ± 0.8

Incidence represents the fraction of animals with observable lesions at any given time post-DFP injection; severity, the average lesion severity score of animals with lesions at any given time point presented as the mean ± SD (animals without lesions were not included in the calculation of the average lesion severity score). N/A, no animals presented with lesions at any given time point; (n=1), data represents score from a single animal;

^*Includes only animals in Group 1;

^**, only animals in Group 2;

^***Combined data from Group 1 and Group 2.