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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Mol Immunol. 2017 Nov 8;113:2–5. doi: 10.1016/j.molimm.2017.10.021

Table 1.

MHC class I-restricted antigen presentation defects observed in DCs deficient in autophagy-related proteins.

Process Autophagy-related protein
Atg5 Atg7 Beclin-1* Vps34 GCN2
Class I surface expression graphic file with name nihms919128ig1.jpg graphic file with name nihms919128ig1.jpg nd graphic file with name nihms919128ig1.jpg nd
Classical pathway graphic file with name nihms919128ig1.jpg nd nd graphic file with name nihms919128ig1.jpg nd
Cross-presentation pathway
 Soluble antigen normal graphic file with name nihms919128ig2.jpg nd normal nd
 Receptor-delivered nd normal nd normal nd
 Bacteria-associated nd nd nd normal nd
 Apoptotic cell-associated normal normal nd graphic file with name nihms919128ig2.jpg nd
 Cells infected with YF-17D graphic file with name nihms919128ig2.jpg graphic file with name nihms919128ig2.jpg graphic file with name nihms919128ig2.jpg nd graphic file with name nihms919128ig2.jpg

Abbreviations: Atg, autophagy-related gene; DC, dendritic cell; GCN2, general control nonderepressible 2; n/a, not applicable; nd, not done; Vps34, vacuolar protein sorting 34; YF-17D, yellow fewer-17D vaccine strain

*

heterozygous null mutant