Table 2.
Cytogenetic abnormalities among 1002 patients with primary myelofibrosis and corresponding comparisons of survival
| Specific abnormalities | Total abnormal N = 449 | Survival comparison vs. Normal karyotype (N = 553) P value (HR; 95% CI) | Survival comparison vs. ‘Unfavorable’ category template (N = 38)a P value (HR; 95% CI) | Survival comparison vs. ‘VHR’ category template (N = 40)b P value (HR; 95% CI) |
|---|---|---|---|---|
| Sole 20q− | 74 | 0.1 (1.3; 0.9–1.7) | 0.02 (0.6; 0.4–0.9) | <0.001 (0.2; 0.1–0.3) |
| Sole 13q− | 56 | 0.08 (0.7; 0.5–1.0)c | <0.001 (0.3; 0.2–0.6) | <0.001 (0.1; 0.06–0.2) |
| Sole +9 | 14 | 0.7 (0.9; 0.4–1.7) | 0.02 (0.4; 0.2–0.8) | <0.001 (0.1; 0.04–0.3) |
| Sole sex chromosome abnormality, including -Y | 19 | 0.6 (0.9; 0.5–1.4) | 0.03 (0.5; 0.3–0.9) | <0.001 (0.1; 0.06–0.3) |
| Sole chromosome 1 translocations/duplications | 21 | 0.7 (1.1; 0.7–1.9) | 0.01 (0.4; 0.2–0.8) | <0.001 (0.1; 0.05–0.3) |
| Sole translocations not involving chromosome 1 | 25 | 0.03 (1.7; 1.1–2.6) | 0.27 (0.7; 0.4–1.3) | <0.001 (0.2; 0.09–0.4) |
| Sole +8 | 26 | <0.001 (2.2; 1.4–3.3) | – | <0.001 (0.4; 0.2–0.7) |
| Sole 7q− | 12 | 0.009 (2.3; 1.2–4.3) | – | 0.008 (0.4; 0.2–0.8) |
| Sole autosomal trisomies, other than +9 or +8 | 15 | <0.001 (3.8; 2.1–6.6) | 0.19 (1.6; 0.8–3.1) | 0.12 (0.6; 0.3–1.1) |
| Sole abnormalities not otherwise classified | 31 | 0.008 (1.7; 1.1–2.5) | 0.33 (0.8; 0.5–1.3) | <0.001 (0.3; 0.2–0.5) |
| Two abnormalities without VHR abnormality | 52 | 0.07 (1.3; 1.0–1.8) | 0.05 (0.6; 0.4–1.0) | <0.001 (0.3; 0.2–0.4) |
| Single/multiple 5q− abnormalities | 11 | 0.28 (1.5; 0.7–3.0) | 0.3 (0.6; 0.3–1.5) | 0.003 (0.2; 0.08–0.6) |
| Single/multiple monosomy 7 abnormalities | 18 | <0.001 (6.3; 3.8–10.4) | 0.005 (2.5; 1.3–4.7) | — |
| Single/multiple 12p−/12p11.2 abnormalities | 11 | <0.001 (5.6; 2.9–10.5) | 0.03 (2.2; 1.1–4.6) | — |
| Single/multiple 11q−/11q23 abnormalities | 13 | <0.001 (3.0; 1.7–5.3) | 0.3 (1.4; 0.7–2.7) | 0.2 (0.6; 0.3–1.3) |
| Single/multiple i(17q)/inv(3) abnormalities | 11 | <0.001 (6.6; 3.6–12.2) | 0.008 (2.8; 1.3–6.0) | — |
| Monosomal karyotype without VHR abnormality | 13 | 0.19 (1.5; 0.8–3.0) | 0.38 (0.7; 0.3–1.5) | 0.002 (0.2; 0.1–0.6) |
| Non-monosomal complex without VHR abnormality | 27 | 0.02 (1.7; 1.1–2.6) | 0.36 (0.8; 0.4–1.3) | <0.001 (0.3; 0.2–0.5) |
a Unfavorable risk category template included sole abnormalities of +8 or 7q−
b Very high risk (VHR) category template included single or multiple abnormalities of −7, inv(3), i(17q) and 12p−/12p11.2
c Trend favoring 13q−
Bold indicates significant differences