Fig. 7.

A chemical screen reveals compounds acting synergistically with AC-4–130. a MOLM-13 and MV4–11 cells were treated with a library of FDA-approved and experimental drugs (10–50 µM) alone or in combination with AC-4–130 (2 µM) for 72 h and cell viability was assessed. b Heatmap of hits defined as compounds giving a viability difference of 50% compared to DMSO controls. c Cell viability of MV4–11 and MOLM-13 cells treated with single drugs or combinations for 24 h. Synergy was assessed using Isobolograms