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. 2018 May 8;8:7189. doi: 10.1038/s41598-018-25320-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Reduced miR-1 and miR-143 levels in PCa-associated tumor stroma. (A) Schematic of normal (N) versus cancer (C) comparison between miRNA levels in xMD microdissected stroma versus epithelium. Stroma was isolated by α-SMA xMD, and epithelium isolated by AE1/AE3 xMD, using JHU samples from Fig. 1B (n = 4). Levels of each miRNA quantified by RT-ddPCR and copy number normalized per 10,000 cel-39. (B) miR-1 and miR-143 levels in normal versus malignant epithelium and stroma. (C) miR-141 and miR-21 levels in normal versus malignant epithelium and stroma. Normal sample values presented from Fig. 2C for comparison. Bars represent mean and standard error. Log Scale. P-values determined by Wilcox Rank Sum analysis. *p < 0.05.