Table 1.
Univariate and Multivariate Cox proportional hazard model on TCGA-PRAD miRNA levels and biochemical recurrence.
| Predictors | HR | HR CI: 2.5% | HR CI: 97.5% | P-value |
|---|---|---|---|---|
| (A) Univariate Analysis | ||||
| Primary Gleason (G2-G3 vs. G4-G5) | 3.275 | 0.582 | 1.791 | 0.000 |
| Stage (T2 vs. T3-T4) | 5.943 | 0.853 | 2.712 | 0.000 |
| Lymphnode status (N0 vs. N1) | 2.014 | 0.07 | 1.33 | 0.029 |
| Stromal content (%) | 1.002 | −0.017 | 0.02 | 0.852 |
| miR-21 expression (continuous) | 2.153 | 0.282 | 1.252 | 0.002 |
| miR-21 expression (dichotomous) | 2.796 | 0.475 | 1.581 | 0.000 |
| miR-1 expression (continuous) | 0.699 | −0.636 | −0.08 | 0.012 |
| miR-1 expression (dichotomous) | 0.245 | −2.259 | −0.555 | 0.001 |
| miR-141 (continuous) | 1.018 | −0.216 | 0.251 | 0.883 |
| miR-141 expression (dichotomous) | 0.39 | −1.87 | −0.013 | 0.047 |
| miR-143 (continuous) | 0.93 | −0.402 | 0.256 | 0.666 |
| miR-143 expression (dichotomous) | 0.416 | −1.799 | 0.048 | 0.063 |
| (B) Multivariate Analysis | ||||
| Primary Gleason + Stage | ||||
| Primary Gleason (G2-G3 vs. G4-G5) | 2.227 | 0.158 | 1.443 | 0.015 |
| Stage (T2 vs. T3-T4) | 3.519 | 0.272 | 2.245 | 0.012 |
| Primary Gleason + Lymphnode status | ||||
| Primary Gleason (G2-G3 vs. G4-G5) | 3.234 | 0.499 | 1.849 | 0.001 |
| Lymphnode status (N0 vs. N1) | 1.439 | −0.271 | 0.999 | 0.261 |
| Primary Gleason + Stage + Lymphnode status | ||||
| Primary Gleason (G2-G3 vs. G4-G5) | 2.131 | 0.053 | 1.46 | 0.035 |
| Stage (T2 vs. T3-T4) | 4.136 | 0.317 | 2.522 | 0.012 |
| Lymphnode status (N0 vs. N1) | 1.272 | −0.399 | 0.881 | 0.461 |
| Primary Gleason + Stage + Lymphnode status + miR-21 | ||||
| Primary Gleason (G2-G3 vs. G4-G5) | 1.964 | −0.042 | 1.392 | 0.065 |
| Stage (T2 vs. T3-T4) | 3.976 | 0.264 | 2.497 | 0.015 |
| Lymphnode status (N0 vs. N1) | 1.192 | −0.471 | 0.822 | 0.595 |
| miR-21 expression (dichotomous) | 1.816 | 0.015 | 1.178 | 0.044 |
| Primary Gleason + Stage + Lymphnode status + miR-1 | ||||
| Primary Gleason (G2-G3 vs. G4-G5) | 1.843 | −0.099 | 1.322 | 0.092 |
| Stage (T2 vs. T3-T4) | 3.734 | 0.215 | 2.42 | 0.019 |
| Lymphnode status (N0 vs. N1) | 1.127 | −0.525 | 0.765 | 0.716 |
| miR-1 expression (dichotomous) | 0.392 | −1.896 | 0.021 | 0.055 |
| Primary Gleason + Stage + miR-1 + miR-21 | ||||
| Primary Gleason (G2-G3 vs. G4-G5) | 1.824 | −0.06 | 1.262 | 0.075 |
| Stage (T2 vs. T3-T4) | 2.978 | 0.09 | 2.093 | 0.033 |
| miR-1 expression (dichotomous) | 0.478 | −1.635 | 0.159 | 0.107 |
| miR-21 expression (dichotomous) | 1.754 | −0.015 | 1.139 | 0.056 |