Table 1.
Clinico-pathological features of 66 intrahepatic cholangiocarcinomas included in the study.
| Clinico-pathological features | Poor 33 | Good 33 | Total 66 | p-value* |
|---|---|---|---|---|
| Sex | 9F 24M | 16F 17M | 25F 41M | 0.13 |
| Age | 67.8 ± 9.7 | 60.6 ± 13.6 | 65.0 ± 11.8 | 0.334^ |
| Dimension (cm) | 6.7 ± 4.4 | 6.1 ± 2.6 | 6.4 ± 3.6 | 0.478^ |
| Median Follow-up (months) | 17.1 | 61.3 | 40.7 | <0.0001# |
| Range | (2.0–40.0) | (40.7–152.7) | (2.0–152.7) | |
| Median DFS (months) | 7.4 | 61.7 | 14.2 | <0.0001# |
| Range | (2.8–26.4) | (34.0–152.7) | (6.3–152.7) | |
| NA | 10 | 14 | 24 | |
| Recurrence | ||||
| 1 | 22 | 11 | 33 | 0.006 |
| 0 | 1 | 8 | 9 | |
| NA | 10 | 14 | 24 | |
| TNM Stage | ||||
| 1 | 2 | 10 | 12 | 0.084 |
| 2 | 12 | 8 | 20 | |
| 3 | 7 | 5 | 12 | |
| 4 | 12 | 10 | 22 | |
| Grade | ||||
| 1 | 3 | 4 | 7 | 0.226 |
| 2 | 19 | 24 | 43 | |
| 3 | 11 | 5 | 16 | |
| R | ||||
| 2 | 1 | 0 | 1 | 0.278 |
| 1 | 5 | 2 | 7 | |
| 0 | 27 | 31 | 58 | |
| Liver fluke status | ||||
| Positive | 0 | 0 | 0 | — |
| Negative | 33 | 33 | 66 | |
| HBV/HCV infection | ||||
| Positive | 4 | 0 | 4 | 0.11 |
| Negative | 29 | 33 | 62 | |
| Primary sclerosing cholangitis | ||||
| Positive | 0 | 0 | 0 | — |
| Negative | 33 | 33 | 66 | |
| Biliary stone disease | ||||
| Positive | 0 | 1 | 1 | — |
| Negative | 33 | 32 | 65 | |
| Liver cirrhosis | ||||
| Positive | 7 | 0 | 7 | 0.011 |
| Negative | 26 | 33 | 59 | |
| Multiple nodes | ||||
| Present | 16 | 10 | 26 | 0.207 |
| Absent | 17 | 23 | 40 | |
| Presence of BIN | ||||
| Present | 8 | 3 | 11 | 0.185 |
| Absent | 25 | 30 | 55 | |
| Vascular invasion | ||||
| Present | 28 | 20 | 48 | 0.051 |
| Absent | 5 | 13 | 18 | |
| Perineural invasion | ||||
| Present | 17 | 13 | 30 | 0.458 |
| Absent | 16 | 20 | 36 | |
Note: BIN, biliary intraepithelial neoplasia; DFS, disease free survival; NA, not available; R, resection margins. *Fisher exact test for multiple comparison was used as appropriated; ^Unpaired t-test; # Kaplan-Maier analysis.