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. 2018 May 8;8:7244. doi: 10.1038/s41598-018-25726-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of MTHFR C677T, A1298C and MTRR A66G genotypes. (a) wild-type CC genotype of MTHFR C677T, (b) heterozygous CT genotype of MTHFR C677T, (c) homozygous mutant TT genotype of MTHFR C677T, (d) wild-type AA genotype of MTHFR A1298C, (e) heterozygous AC genotype of MTHFR A1298C, (f) homozygous mutant CC genotype of MTHFR A1298C, (g) wild-type AA genotype of MTRR A66G, (h) heterozygous AG genotype of MTRR A66G, (i) homozygous mutant GG genotype of MTRR A66G, (j) the primers of MTHFR and MTRR.