Table 2.
Detection of 5 variants that showed strong association with PVL scores (P < 0.01 by means of exact Fisher’s test) in 42 SIV-infected cynomolgus macaques.
| Gene | Chr. | Location of SNP on chromosome* | P-value by exact test | Odds ratio | P-value | 95% Cl | interaction with SIV |
|---|---|---|---|---|---|---|---|
| UMODL1 Uromodulin-Like 1 | 3 | 4,684,432 | 2.4 × 10−3 | 5.9 | 1.2 × 10−3 | 1.376–29.542 | see note “$“ |
| SLC26A8 Solute Carrier Family 26 (Anion Exchanger), Member 8 | 4 | 134,811,277 | 4.3 × 10−3 | >8.9 | 9.1 × 10−3 | 1.583 - Inf | most probably none |
| MYH13 myosin 13 | 16 | 10,498,978 | 5.4 × 10−3 | 4.9 | 2.6 × 10−2 | 1.129–24.526 | most probably none |
| MYH8 myosin 8 | 16 | 10,573,814 | 5.4 × 10−3 | 4.9 | 2.6 × 10−2 | 1.129–24.526 | most probably none |
| LOC102139876 melanoma-associated antigen D4 | X | 50,696,215 | 7.9 × 10−3 | 7.5 | 7.9 × 10−3 | 1.468–53.826 | most probably none |
*The positions are based on the assembly of the Macaca fascicularis genome MacFas5.0 (GCA 000364345.1).
$Uromodulin-Like 1 (olfactorin): Knockdown of uromodulin-like 1 (UMODL1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1.