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. 2018 May 8;8:7292. doi: 10.1038/s41598-018-24064-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Defective AC development in Linx^+/− mice. (A) A defect in IC development found in Linx^−/− mice. The coronal sections of brains from Linx^+/+ (left) and Linx^−/− (right) E19 embryonic mice were stained for L1, a neuronal adhesion molecule, to visualize the IC. An arrowhead denotes the remnants of the descending component of the IC. Boxed areas were magnified in the adjacent panels. (B–D) Transmitted light (B), Nissl-stained (C), and KB-stained (D) images of coronal sections from P30 mouse brains showing the defects in the AC of Linx^+/− mice. ACp, posterior branch of the AC; ACa, anterior branch of the AC; TH, thalamus; HC, hippocampal commissure; BST, bed nuclei of the stria terminalis. (E) Horizontal sections from the brains of wild-type (left) and Linx^+/− (right) mice showing defective AC development in Linx^+/− mice. Boxed areas are magnified in the lower panels. (F) The axon tract from the AON was labeled with DiI crystals placed around the AON regions prepared from wild-type and Linx^+/− mice. The axon tract that constitutes the anterior branch of the AC was short and disrupted in Linx^+/− mice compared with wild-type mice. Boxed areas are magnified in the adjacent panels. (G) A schematic illustration representing the neural projections regulated by Linx; this is based on data from both previous¹² and present studies.