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. 2018 May 8;8:7292. doi: 10.1038/s41598-018-24064-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Interaction of Linx with RTKs and its effect on ERK signaling. (A) Linx interaction with Ret. Lysates from N1E-115 cells were immunoprecipitated (IP) using Linx (left) and Ret51 (right; an isoform of Ret) antibodies, followed by Western blot analysis with the indicated antibodies. Asterisks indicate co-immunoprecipitated Ret51 and Linx. TCL, total cell lysates. Full blot images are shown in Supplementary Figure S3. (B) Linx interaction with TrkA. Lysates from N1E-115 cells transfected with either control or Linx-V5 vector were immunoprecipitated with V5 antibody, followed by Western blot analysis. Asterisks indicate co-immunoprecipitated TrkA. Full blot images are shown in Supplementary Figure S3. (C) N1E-115 cells transfected with either control or Linx-V5 vector were starved and stimulated with GDNF, followed by Western blot analysis using the indicated antibodies. Full blot images are shown in Supplementary Figure S3.