Table 1.
Results of Mendelian randomization analysis for CAD on LOAD.
| Risk Phenotype | Variant count | OR for LOAD[95% CI] | p-value | Cochran’s Q | df | p-value |
|---|---|---|---|---|---|---|
| CAD (GWS) | 52 | 1.07 [1.01–1.15] | 0.027 | 1868.13 | 51 | <2.2 × 10−308 |
| CAD (GWS) (Excluding APOE) | 51 | 0.94 [0.88–1.01] | 0.072 | 53.22 | 50 | 0.351 |
| CAD (GWS) Egger MR | 52 | 1.09 [0.47–2.54] | 0.846 | 1868.13 | 51 | <2.2 × 10−308 |
| CAD (FDR) | 190 | 1.05 [1.01–1,10] | 0.024 | 2059.25 | 189 | <2.2 × 10−308 |
| CAD (FDR) (Excluding APOE) | 189 | 0.99 [0.94–1.03] | 0.553 | 247.40 | 188 | 0.002 |
Results of the analysis of summary statistics from CAD and LOAD. GWS is Genome Wide Significant (p ≥ 5 × 10−8); FDR is a false discovery rate of 5%. APOE refers to the rs4420638 variant within the APOE locus.