Table 1.
Hippocampal formation subfield | DG | CA4 | CA3 | CA2 | CA1 | Subiculum | P-value |
---|---|---|---|---|---|---|---|
Epileptiform-like activity | |||||||
Interictal-like event | |||||||
Slices (n) | 19 | 18 | 9 | 5 | 8 | 11 | |
Events/minb | 21.7 ± 1.9 | 18.0 ± 0.8 | 15.0 ± 1.1 | 22.0 ± 1.2 | 14.0 ± 1.6 | 21.8 ± 0.9 | 0.0004 |
Amplitude (mV)b | 1.0 ± 0.1 | 0.3 ± 0.02 | 0.2 ± 0.04 | 0.2 ± 0.01 | 0.2 ± 0.01 | 0.9 ± 0.1 | 0.0001 |
Duration (sec)b | 0.7 ± 0.1 | 0.4 ± 0.04 | 0.4 ± 0.04 | 0.4 ± 0.1 | 0.3 ± 0.01 | 0.7 ± 0.04 | 0.0033 |
Periodic ictal spiking | |||||||
Slices (n) | 10 | — | — | 5 | 2 | 9 | |
Events/minb | 52.5 ± 2.1 | — | — | 103.6 ± 5.9 | 42.5 ± 1.4 | 48.1 ± 2.4 | 0.0024 |
Amplitude (mV)b | 1.1 ± 0.1 | — | — | 0.3 ± 0.03 | 0.4 ± 0.02 | 0.9 ± 0.01 | 0.0028 |
Duration (sec)b | 0.4 ± 0.03 | — | — | 0.2 ± 0.03 | 0.2 ± 0.01 | 0.12 ± 0.03 | 0.0004 |
Seizure-like events | |||||||
Slices (n) | 26 | 1 | — | — | 1 | 4 | |
Events/min | 1.5 ± 0.2 | 0.7 ± 0.2 | — | — | 1.5 ± 0.4 | 0.9 ± 0.2 | |
Amplitude (mV)a | 2.6 ± 0.1 | 0.8 ± 0.1 | — | — | 0.6 ± 0.1 | 1.2 ± 0.1 | 0.0007 |
Duration (sec) | 28.9 ± 3.1 | 17.2 ± 2.0 | — | — | 15.6 ± 3.2 | 19.3 ± 0.8 | |
Spreading depression-like event | |||||||
Slices (n) | 2 | — | 1 | — | 1 | 2 | |
Events/min | 1 | — | 1 | — | 1 | 1 | |
Amplitude (mV) | 5.3 ± 0.4 | — | 3.2 | — | 2.3 | 1.2 ± 0.1 | |
Duration (sec) | 35.5 ± 3.9 | — | 57.6 | — | 105.8 | 51.1 ± 5.2 | |
Tonic seizure-like events | |||||||
Slices (n) | 2 | — | — | — | — | — | |
Events/min | 1.1 ± 0.2 | — | — | — | — | — | |
Amplitude (mV) | 2.6 ± 0.54 | — | — | — | — | — |
aP-values are indicated where significant difference for group were observed using Mann-Whitney-Wilcoxon U test. bP-values are indicated where significant difference for group were observed using Kruskal-Wallis H test. All data are expressed as mean ± SEM.