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. 2018 May 8;8:7116. doi: 10.1038/s41598-018-25378-9

Table 1.

Parameter values of the different patterns of epileptiform activity in hippocampal formation subfields.

Hippocampal formation subfield DG CA4 CA3 CA2 CA1 Subiculum P-value
Epileptiform-like activity
Interictal-like event
Slices (n) 19 18 9 5 8 11
Events/minb 21.7 ± 1.9 18.0 ± 0.8 15.0 ± 1.1 22.0 ± 1.2 14.0 ± 1.6 21.8 ± 0.9 0.0004
Amplitude (mV)b 1.0 ± 0.1 0.3 ± 0.02 0.2 ± 0.04 0.2 ± 0.01 0.2 ± 0.01 0.9 ± 0.1 0.0001
Duration (sec)b 0.7 ± 0.1 0.4 ± 0.04 0.4 ± 0.04 0.4 ± 0.1 0.3 ± 0.01 0.7 ± 0.04 0.0033
Periodic ictal spiking
Slices (n) 10 5 2 9
Events/minb 52.5 ± 2.1 103.6 ± 5.9 42.5 ± 1.4 48.1 ± 2.4 0.0024
Amplitude (mV)b 1.1 ± 0.1 0.3 ± 0.03 0.4 ± 0.02 0.9 ± 0.01 0.0028
Duration (sec)b 0.4 ± 0.03 0.2 ± 0.03 0.2 ± 0.01 0.12 ± 0.03 0.0004
Seizure-like events
Slices (n) 26 1 1 4
Events/min 1.5 ± 0.2 0.7 ± 0.2 1.5 ± 0.4 0.9 ± 0.2
Amplitude (mV)a 2.6 ± 0.1 0.8 ± 0.1 0.6 ± 0.1 1.2 ± 0.1 0.0007
Duration (sec) 28.9 ± 3.1 17.2 ± 2.0 15.6 ± 3.2 19.3 ± 0.8
Spreading depression-like event
Slices (n) 2 1 1 2
Events/min 1 1 1 1
Amplitude (mV) 5.3 ± 0.4 3.2 2.3 1.2 ± 0.1
Duration (sec) 35.5 ± 3.9 57.6 105.8 51.1 ± 5.2
Tonic seizure-like events
Slices (n) 2
Events/min 1.1 ± 0.2
Amplitude (mV) 2.6 ± 0.54

aP-values are indicated where significant difference for group were observed using Mann-Whitney-Wilcoxon U test. bP-values are indicated where significant difference for group were observed using Kruskal-Wallis H test. All data are expressed as mean ± SEM.