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. 2018 May 8;8:7188. doi: 10.1038/s41598-018-24056-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CCR2 mediates post-UTI chronic pain. Values represent mean ± S.D. (A) Female B6 mice were infected with E. coli strain SΦ874. On PID 16, mice received i.p. injection of 10 mg/kg CCR2-RA or vehicle (n = 5 each group). Mice receiving CCR2-RA exhibited significantly decreased allodynia (*P < 0.05). (B) Mice were infected with UPEC strain NU23 (n = 8). On PID 14, female B6 mice were evaluated for allodynia relative to baseline. Mice were then re-evaluated after administration of 20 mg/kg CCR2-RA. CCR2-RA significantly reduced allodynia induced by NU23 (*P < 0.03).