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. 2018 May 8;8:7110. doi: 10.1038/s41598-018-25569-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ligands of TGR5 do not influence contraction of NMVMs. Contraction rate of NRVMs following treatment with INT77 (a) and UDCA and its conjugates (b) at 10–100 μM (n = 6, *p < 0.05, **p < 0.01); (c) Contraction of WT NMVMs in comparison to TGR5KO following treatment with INT 777 (100 μM) (n ≥ 6, ns, one-way ANOVA). (d) Effect of INT 777 (100 μM) on WT adult mouse cardiomyocytes contraction (n = 9, ns, unpaired t-test). All treatment were given acutely, following 10–15 mins perfusion. Data presented as mean ± SEM.