Table 4.

Time for maximum positive increase in signal unit ratio depending on anatomical region.

Anatomical region	Time after intrathecal gadobutrol
	2–4 hours	4–6 hours	6–9 hours	24 hours	48 hours	aSignificance
Cerebrospinal fluid	3	8	7	1	0	=0.005
Inferior frontal gyrus	0	0	0	17	1	=0.10
Parahippocampal gyrus	0	3	1	13	1	=0.58
Thalamus	2	2	0	12	2	=0.65
Pons	1	2	1	10	4	=0.66
Cervical lymph node	2	2	2	10	1

Data represented by number of individuals within each category (only including individuals with positive change in signal unit ratio at the different time points for each anatomical region). ^aSignificance: Difference with concern to time point of peak enhancement as compared to time point of peak enhancement in cervical lymph node (Pearson Chi-square test).