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. 2018 May 8;8:7124. doi: 10.1038/s41598-018-25640-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of endosomal acidification with NH₄Cl or bafilomycin A1 inhibits HCoV-OC43 infection in HCT-8 cell line. The infection efficiency determined with flow cytometry is expressed as the percentage of HCoV-OC43 infected cells, compared to the untreated control, and is presented on the left side of the graph. Right part of the graph shows the cell viability, as determined with an XTT assay. NH₄Cl −50 mM NH₄Cl; BafA1 −2.5 nM bafilomycin A1; control – PBS; M – mock infected cells; V or + − HCoV-OC43 infected cells. The data is presented as the mean of a triplicate for each sample ± SD. To determine the significance of differences between compared groups, Single-Factor Analysis of Variance (ANOVA) was applied. ***P values < 0.05 were considered significant.