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. 2018 May 8;8:7249. doi: 10.1038/s41598-018-25397-6

Figure 1.

Figure 1

Treatment with metformin improves glucose and insulin tolerance in animals on high-fat diet. Panel A shows blood glucose profiles during oral glucose tolerance test (OGTT); Panel C shows blood glucose profiles during intraperitoneal insulin tolerance test (IPTT). Panels B and D show respective areas under blood glucose concentration curve (AUC) from OGTT and IPTT tests. Values are mean +/− SD. Symbols denote statistical significance of p < 0.05 against: a- vs. Control group; *- vs. HFD group, n = 8 per group; Significance by Anova with Tukey HSD post-hoc test.