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. 2018 May 8;8:7249. doi: 10.1038/s41598-018-25397-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Metformin treatment normalizes hepatic content an synthesis rate of ceramide and diacylglycerol in the liver of rats fed HFD diet. Panel A and B present a total ceramide and diacylglycerol content in rat liver, respectively; Panels in the C row show the content of ceramide and diacylglycerol molecular species with established FSR. Panels in the D row present respective FSR values of the individual lipid species from the panels in the C row. Panel E and F present hepatic protein content of SPT and CerS4. Values are mean +/− SD. Symbols denote statistical significance of p < 0.05 versus: a- vs. Control group; *- vs. HFD group. n = 8 per group; Significance by Anova with Tukey HSD post-hoc test.