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. 2018 May 8;8:7264. doi: 10.1038/s41598-018-24203-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MiRNA profiling of cord blood myeloid progenitors, monocytes and neutrophils. Normalised TaqMan Low-Density Array (TLDA) profiles of miRNA expression in (a) monocytes vs. myeloid progenitors and (b) granulocytes vs. myeloid progenitors from human cord blood. MiRNAs with ≥ 2-fold increased expression in the mature cell types are shown in red and those with ≥ 2-fold decreased expression are shown in green. (c) Number of miRNAs increased ≥ 2-fold or more in each comparison. (d) Top panel: miRNAs with a ≥ 2-fold increase in both cell types. Middle and lower panel: miRNAs that are increased in both cell types and are clustered together in the genome. (e) Number of miRNAs decreased ≥ 2-fold in each comparison. (f) Top panel: the five miRNAs of the same family (highly similar seeds) that are decreased in both mature cell types relative to the progenitor. Middle and lower panels: miRNAs that decreased in both comparisons and are clustered together in the genome.