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. 2018 May 8;8:7264. doi: 10.1038/s41598-018-24203-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The miR-223, miR-125b and mir-10a regulatory circuits in human hematopoiesis. miR-223 regulates myeloid differentiation via the transcription factors LMO, MEF2C, NFI-A, and E2F1. The latter two are themselves negative regulators of miR-223 expression and thus fine-tune miR-223 in a negative feedback loop (a). miR-125b is involved in the regulation of T-cell and B-cell differentiation as well as granulopoiesis by repressing the expression of a number of different transcription factors. We found that miR-125b expression is inhibited by IL-3 and SCF, among other regulators (b). miR-10a is another regulator of myeloid and lymphoid differentiation targeting BCL-6 and NCOR2 in lymphopoiesis, USF2 and HOXA1 in megakaryocytopoiesis, and KLF4 in monocytopoiesis.