Table 3.
The top 15 categories from gene ontology analysis performed on the top 2000 differentially expressed transcripts using the Panther database’s statistical over representation test with Bonferroni correction (www.pantherdb.org).
| GO biological process complete | Fold enrichment | p-value |
|---|---|---|
| Progenitors vs. Monocytes | ||
| regulation of mast cell activation (GO:0033003) | 3.98 | 4.22E-02 |
| regulation of myeloid leukocyte mediated immunity (GO:0002886) | 3.98 | 4.22E-02 |
| regulation of B cell proliferation (GO:0030888) | 3.48 | 2.19E-02 |
| regulation of alpha-beta T cell activation (GO:0046634) | 3.30 | 5.91E-03 |
| toll-like receptor signaling pathway (GO:0002224) | 3.00 | 1.84E-02 |
| purine ribonucleoside biosynthetic process (GO:0046129) | 2.95 | 1.56E-02 |
| purine nucleoside biosynthetic process (GO:0042451) | 2.95 | 1.56E-02 |
| nucleoside biosynthetic process (GO:0009163) | 2.94 | 5.12E-04 |
| pattern recognition receptor signaling pathway (GO:0002221) | 2.92 | 2.17E-03 |
| glycosyl compound biosynthetic process (GO:1901659) | 2.89 | 7.45E-04 |
| purine nucleotide biosynthetic process (GO:0006164) | 2.89 | 2.12E-04 |
| positive regulation of lymphocyte proliferation (GO:0050671) | 2.88 | 1.48E-04 |
| positive regulation of mononuclear cell proliferation (GO:0032946) | 2.84 | 2.14E-04 |
| ribonucleoside biosynthetic process (GO:0042455) | 2.82 | 6.51E-03 |
| positive regulation of leukocyte proliferation (GO:0070665) | 2.81 | 1.79E-04 |
| Progenitors vs. Granulocytes | ||
| maturation of LSU-rRNA (GO:0000470) | 6.41 | 2.42E-04 |
| neutrophil activation (GO:0042119) | 5.87 | 3.73E-02 |
| granulocyte activation (GO:0036230) | 5.82 | 1.51E-02 |
| ribosomal large subunit biogenesis (GO:0042273) | 3.88 | 3.31E-04 |
| SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.34 | 2.03E-04 |
| myeloid leukocyte activation (GO:0002274) | 3.32 | 4.57E-05 |
| viral gene expression (GO:0019080) | 3.14 | 2.57E-05 |
| cotranslational protein targeting to membrane (GO:0006613) | 3.08 | 1.11E-03 |
| protein targeting to ER (GO:0045047) | 3.08 | 1.11E-03 |
| rRNA metabolic process (GO:0016072) | 3.03 | 5.71E-13 |
| rRNA processing (GO:0006364) | 3.03 | 1.45E-12 |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.03 | 2.55E-04 |
| mitochondrial translational elongation (GO:0070125) | 3.02 | 2.71E-02 |
| ribosome biogenesis (GO:0042254) | 2.99 | 1.45E-15 |
| translational termination (GO:0006415) | 2.99 | 1.29E-02 |