Fig. 6.

MetaXcan framework and application. a Shows a general framework (MetaXcan) which encompasses methods such as PrediXcan, TWAS, SMR, COLOC among others. b Summarizes the application of the MetaXcan framework with S-PrediXcan using 44 GTEx tissue transcriptomes and over 100 GWAS and meta analysis results. We trained prediction models using elastic-net²⁶ and deposited the weights and SNP covariances in the publicly available resource (http://predictdb.org/). The weights, covariances, and over 100 GWAS summary results were processed with S-PrediXcan. Colocalization status was computed and the full set of results was deposited in gene2pheno.org