Fig. 8.

S-PrediXcan associations in different tissues. a Displays associations for PCSK9, SORT1, and C4A on relevant traits by tissue. This figure shows the association strength between three well studied genes and corresponding phenotypes. C4A associations with schizophrenia (SCZ) are significant across most tissues. SORT1 associations with LDL-C, coronary artery disease (CAD), and myocardial infarction (MI) are most significant in liver. PCSK9 associations with LDL-C, coronary artery disease (CAD), and myocardial infarction (MI) are most significant in tibial nerve. The size of the points represent the significance of the association between predicted expression and the traits indicated on the top labels. Red indicates negative correlation whereas blue indicates positive correlation. $R_{\mathrm{pred}}^2$ is a performance measure computed as the correlation squared between observed and predicted expression, cross validated in the training set. Darker points indicate larger genetic component and consequently more active regulation in the tissue. b Displays a histogram of the number of tissues for which a gene is significantly associated with height (other phenotypes show a similar pattern). Tissue abbreviations: ADPSBQ Adipose-Subcutaneous, ADPVSC Adipose-Visceral(Omentum), ADRNLG Adrenal Gland, ARTAORT Artery-Aorta, ARTCRN Artery-Coronary, ARTTBL Artery-Tibial, BLDDER Bladder, BRNAMY Brain-Amygdala, BRNACC Brain-Anterior cingulate cortex (BA24), BRNCDT Brain-Caudate(basal ganglia), BRNCHB Brain-Cerebellar Hemisphere, BRNCHA Brain-Cerebellum, BRNCTXA Brain-Cortex, BRNCTXB Brain-Frontal Cortex (BA9), BRNHPP Brain-Hippocampus, BRNHPT Brain-Hypothalamus, BRNNCC Brain Nucleus accumbens(basal ganglia), BRNPTM Brain-Putamen (basal ganglia), BRNSPC Brain-Spinal cord(cervical c-1), BRNSNG Brain-Substantia nigra, BREAST Breast-Mammary Tissue, LCL Cells-EBV-transformed lymphocytes, FIBRBLS Cells-Transformed fibroblasts, CVXECT Cervix-Ectocervix, CVSEND Cervix-Endocervix, CLNSGM Colon-Sigmoid, CLNTRN Colon-Transverse, ESPGEJ Esophagus-Gastroesophageal Junction, ESPMCS Esophagus-Mucosa, ESPMSL Esophagus-Muscularis, FLLPNT Fallopian Tube, HRTAA Heart-Atrial Appendage, HRTLV Heart-Left Ventricle, KDNCTX Kidney-Cortex, LIVER Liver, LUNG Lung, SLVRYG Minor Salivary Gland, MSCLSK Muscle-Skeletal, NERVET Nerve-Tibial, OVARY Ovary, PNCREAS Pancreas, PTTARY Pituitary, PRSTTE Prostate, SKINNS Skin-Not Sun Exposed (Suprapubic), SKINS Skin-Sun Exposed (Lower leg), SNTTRM Small Intestine-Terminal Ileum, SPLEEN Spleen, STMACH Stomach, TESTIS Testis, THYROID Thyroid, UTERUS Uterus, VAGINA Vagina, WHLBLD Whole Blood