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. 2018 May 8;8:7238. doi: 10.1038/s41598-018-25500-x

Table 2.

The major ingredients and major targets of the 18 herbs involved in CRC treatment.

Chinese Name Latin name Major ingredients Number of targets Major targets Frequency
(%)		 Average dosage(g) Correlation coefficient P value
graphic file with name 41598_2018_25500_Figa_HTML.gif Lycii Fructus Quercetin (LF22) 11 TNF
RXRA
TOP2		 12.6 10 0.35 0.002
graphic file with name 41598_2018_25500_Figb_HTML.gif Magnolia Officinalis Rehd Et Wils. Honokiol (MO18)
Magnolol (MO20)		 6 TNF
RXRA
TOP2		 15.2 6 0.346 0.003
graphic file with name 41598_2018_25500_Figc_HTML.gif Radix Clematidis Nonane (RC6)
Palmitic acid (RC7)
Stigmasterol (RC8)		 3 TNF
RXRA
PPARG		 24.2 10 0.315 0.007
graphic file with name 41598_2018_25500_Figd_HTML.gif Aucklandiae Radix (R)-linalool (AR5) 5 RXRA 43.5 5 0.282 0.017
graphic file with name 41598_2018_25500_Fige_HTML.gif Angelicae Sinensis Radix Stigmasterol (ASR16) 4 RXRA 52.0 10 0.28 0.018
graphic file with name 41598_2018_25500_Figf_HTML.gif Xanthii Fructus Emodin (XF14) 10 TNF
RXRA
TOP2
SRC		 11.5 9 0.274 0.021
graphic file with name 41598_2018_25500_Figg_HTML.gif Eriocauli Flos Quercetin (EF10) 12 TOP2 18.5 30 0.274 0.021
graphic file with name 41598_2018_25500_Figh_HTML.gif Cassiae Semen Emodin (XF8) 9 RXRA
TOP2
TNF		 16.6 10 0.274 0.021
graphic file with name 41598_2018_25500_Figi_HTML.gif Fallopia multiflora Emodin (FM1) 6 TOP2
TNF		 10.2 30 0.274 0.021
graphic file with name 41598_2018_25500_Figj_HTML.gif Selaginella Doederleinii Hieron Apigenin (SDH2) 6 TOP2 31.1 30 0.272 0.022
graphic file with name 41598_2018_25500_Figk_HTML.gif Herba Patriniae luteolin (EF4) 6 AKT1
PPARG		 71.0 30 0.271 0.022
graphic file with name 41598_2018_25500_Figl_HTML.gif Portulacae Herba Luteolin (PH15)
Myricetin (PH17)
Quercetin (PH22)		 20 RXRA
PPARG
SRC		 33.6 30 0.263 0.027
graphic file with name 41598_2018_25500_Figm_HTML.gif Coicis
Semen 		Oleic acid (CoS6) 6 RXRA 14.7 30 0.254 0.032
graphic file with name 41598_2018_25500_Fign_HTML.gif Taraxacum mongolicum Hand Quercetin (TM7) 14 RXRA
TOP2		 15.3 10 0.247 0.038
graphic file with name 41598_2018_25500_Figo_HTML.gif Phytolaccae Radix Quercetin (PR8)
Apigenin (PR16)
Luteolin (PR18)
Ursolic acid (PR19)		 23 RXRA
TOP2		 71.8 30 0.246 0.039
graphic file with name 41598_2018_25500_Figp_HTML.gif Ranunculi Ternati Radix Oleic acid (RTR8) 5 RXRA 60.4 30 0.244 0.04
graphic file with name 41598_2018_25500_Figq_HTML.gif Schisandrae Chinensis Fructus Protocatechuic acid (SCF1)
Arnebin 7 (SCF2)
Gomisin T (SCF3) Schisanhenol (SCF4)		 2 PPARG 42.0 6 0.244 0.041
graphic file with name 41598_2018_25500_Figr_HTML.gif Radix Paeoniae Rubra Oleic acid (RPR13)
Paeonol (RPR15)		 7 RXRA
TOP2
TNF
AKT1		 8.9 20 0.236 0.048