Fig. 5.
Silencing of forebrain pyramidal neurons improved the initial orientation to the goal location during a 24-HR probe. A) Escape latencies during training did not differ between CON and ATD animals (CON, n = 18; ATD, n = 9). B) Number of platform crossings during the 24-HR probe did not differ between CON and ATD animals during the 24HP probe. C) Both CON and ATD animals showed a preference for the goal quadrant during the 24HP**p < 0.005 E) DtP measured across 10 s of the 24HP did not differ between CON and ATD animals. The black circle on the Y-axis indicates the platform edge. The open circle marks starting location for all animals (710 mm). F) The first 10 s of the normalized DtP 24HP was reduced for the ATD animals compared to the CON animals [F(1,26) = 6.166, p < 0.05]; * = p < 0.05.