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. Author manuscript; available in PMC: 2018 Sep 15.
Published in final edited form as: Brain Res. 2017 Jun 27;1671:1–13. doi: 10.1016/j.brainres.2017.06.024

Fig. 6.

Fig. 6

AlstR activation in hippocampal slices did not alter baseline synaptic transmission but attenuated synaptic facilitation at 5 Hz and AP accommodation at 100 Hz stimulation. One hundred stimulus pulses were applied at 5 (CON, n = 18; ATD, n = 8) or 100 Hz (CON, n = 13; ATD, n = 7). A) Waveforms show all responses across a 100 Hz burst (top, 1 s) or only the first four responses (bottom, 40 ms) for ATD and CON animals. B) Analyses of responses to the first stimulus pulse for all 5 and 100 Hz burst experiments revealed no difference in the mean FP amplitude or mV EPSP slope (CON, n = 18; ATD, n = 12). C) Mean FP amplitude plotted against stimulus number did not differ between groups at 5 Hz stimulation. At 100 Hz, the FP amplitude decreased more during early stimulus pulses (pulse 2–4) for CON slices compared to ATD slices, but decreased more later in the burst (pulses 7–57) for ATD compared to CON slices. * = p < 0.05; *** = p < 0.0001. D) Mean EPSP slope plotted against stimulus number did not differ between groups at 100 Hz stimulation. Synaptic facilitation was reduced in ATD compared to CON animals at 5 Hz. ** = p < 0.001.