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. 2018 May 8;8:7297. doi: 10.1038/s41598-018-25453-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Aβ up-regulates mature BDNF expression and co-localizes with microglia in OHC. Western blot analysis of BDNF expression in OHC slices treated with 2 μM Aβ25-35 for 24 h (A) or 0.5 μM Aβ42 for 7 days (B). Co-localization of FAM-Aβ (green) in CA1 area of OHCs with cell type markers, integrin α-M (red, C) and GFAP (red, D), observed 24 h after its addition to the slices. Scale bar is 20 μm. Values are mean ± SEM with n = 3. *p < 0.05 vs. control by Student’s t-test.