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. 2018 May 8;8:7296. doi: 10.1038/s41598-018-25480-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heparin inhibits Mtb and BCG replication. (A,C) Intracellular CFU in THP-1 macrophages infected with BCG (A) and Mtb (C) at an MOI of 10 after 16 hours of treatment with 50 µg heparin. (B,D) Percentage of intracellular bacilli in heparin treated macrophages at 24, 48 and 72 hours post infection with BCG (B) and Mtb (D). (E) Trypan blue exclusion cell viability in Mtb infected-THP-1 macrophages at 24, 48 and 72 hours post-infection. For a and c macrophages were seeded in 12 well plates Data from three independent experiments. * p < 0.05, **p < 0.01, ***p < 0.001.