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. 2018 May 8;8:7296. doi: 10.1038/s41598-018-25480-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heparin inhibits hepcidin expression in macrophages. (A,B) Hepcidin expression in heparin-treated macrophages 24 hours after LPS stimulation (A) or BCG infection (B) measured by qRT-PCR. (C) Hepcidin secretion in Mtb-infected THP-1 macrophages culture supernatants. (D) Hepcidin secretion by heparin-treated macrophages 48 hours after Mtb or BCG infection. (E) Hepcidin secretion by heparin treated ASC deficient THP-1 macrophages 48 hours after Mtb infection. Data from three independent experiments. *P < 0.05, **p < 0.01, ***p < 0.001.