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. 2018 May 8;8:7296. doi: 10.1038/s41598-018-25480-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hepcidin rescues intracellular Mtb replication in heparin-treated macrophages. (A) Hepcidin mRNA expression in BCG-infected macrophages with and without iron supplementation. (B) Intracellular bacterial burden in heparin-treated macrophages with and without iron supplementation. (C) Intracellular bacterial burden in heparin-treated macrophages in presence of iron chelator deferiprone at 0 and 56 hours post infection. (D) Intracellular bacterial burden in heparin-treated macrophages supplemented with hepcidin synthetic peptide. For b macrophages were seeded in 48 well plates. For c and d macrophages were seeded in 96 well plates. Data from three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.