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. 2018 May 8;8:7222. doi: 10.1038/s41598-018-25588-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increase of intracellular vesicles with TMZ resistance. (a,b) Number of intracellular vesicles stained positive for the early endosomal marker EEA1 quantified between sensitive and resistant cell lines by immunofluorescence. t-test (a) 42MGBA p = <0.0001; (b) 8MBGA p = <0.0001. (c) Representative image of EEA1 immunofluorescence. (d) REMBRANDT dataset Kaplan-Meier overall survival plot with median expression of EEA1 in all brain cancer patients. (e) EEA1 expression in the Chinese Cancer Genome Consortium (CCGC) dataset by brain cancer type. A = astrocytoma; AA = anaplastic astrocytoma; AO = anaplastic oligodendroglioma; AOA = anaplastic oligoastrocytoma; O = oligodendroglioma; OA = oligoastrocytoma; GBM = glioblastoma. r(cancer type) = recurrent, s(cancer type) = secondary. (f) EEA1 expression in the REMBRANDT dataset by cancer type. One-way ANOVA p = <0.0001.