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. 2018 May 8;8:7174. doi: 10.1038/s41598-018-25381-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of SE-EE on scopolamine inflicted cognitive and behavioral impairment in C57/BL6N mice: (a) The design of the experiments with animals; (b) In the step-through passive avoidance test, the latency variance in the acquisition and retention phase was acquired; (c) In the spontaneous alternation performance (Y-maze test), the total arm entry and percentage of alternation was acquired. Data are expressed as mean ± SD (n = 6). One-way ANOVA-Tukey’s multiple comparison test was performed. ^#p < 0.05 compared with the control group; *p < 0.05 other treated groups compared with the scopolamine group.