Table 1.
HLA class II-associated HCV variations from a single source genotype 1B outbreak.
| Protein | Residue | HLA | Consensus | p-value | OR |
|---|---|---|---|---|---|
| NS2 | 834# | DQB1*02 | H | 0.01 | 16 |
| 834# | DRB1*03 | H | <0.001 | 41 | |
| 837 | DRB1*03 | V | 0.006 | 5 | |
| 849 | DQB1*06 | F | 0.009 | 0.1 | |
| 940 | DQB1*06 | R | 0.009 | 0.1 | |
| 1011 | DQB1*03 | L | 0.002 | 0.1 | |
| 1011 | DQB1*06 | L | <0.001 | 11 | |
| 1011 | DRB1*15 | L | 0.001 | 8 | |
| NS5A | 2065 | DRB1*03 | Y | 0.007 | 19 |
| 2138 | DQB1*06 | K | 0.01 | 5.7 | |
| 2138 | DRB1*15 | K | 0.006 | 6.5 | |
| 2356 | DRB1*03 | E | 0.002 | 25 |
Alleles associated with clearance (HLA-DQB1*02 and -DRB1*03) and chronicity (HLA-DQB1*06 and –DRB1*15) in this cohort21. Possible HLA-DRB1 and –DQB1 haplotypes indicated with a box. OR = odds ratio. N = 63. #Indicates possible extended haplotype with HLA class I allele (HLA-B*08).