Table 1.

Dose reduction simulation parameters

Simulation geometry
Detector size	1100 × 1100 pixels
Detector quantum efficiency	80%
Detector pixel size	10 µm
X-ray energy	530 eV
Sample-to-detector distance	5 cm
Pinhole diameter	3 µm
Fluence on dynamic structure	3.5 × 104–3.5 × 107 photons µm−2
Fluence on static structure	1.4 × 1010 photons µm−2
Simulated sample parameters
Maximum dynamic structure thickness (H50C30N9O10S1)	1 µm
Static structure thickness (Au)	20 nm
Protein density	1.35 g cm−3