Table 1.
System | cDNA | Gene | AA substrate | Mechanism | Iron | Expression |
---|---|---|---|---|---|---|
ASC | ASCT2 | SLC1A5 | A,S,C,T,Q | A | Na+ | AM |
B0 | B0AT1 | SLC6A19 | AA0 | S | Na+ | AM |
B0,+ | ATB0,+ | SLC6A14 | AA0, AA+, β-Ala | S | Na+, Cl− | AM |
b0,+ | rBAT/b0,+AT | SLC3A1/SLC7A9 | R,K,O | A | – | AM |
IMINO | IMINO | SLC6A20 | P,HO-P | S | Na+, Cl− | AM |
L | 4F2hc/LAT2 | SLC3A2/SLC7A8 | AA0 except P | A | – | BM |
PAT | PAT1 | SLC36A1 | P,G,A,β-Ala | S | H+ | BM |
T | TAT1 | SLC16A10 | F,Y,W | U | – | BM |
X−AG | EAAT3 | SLC1A1 | E,D | S | Na+, H+, K+ | AM |
y+L | 4F2hc/y+LAT1 | SLC3A2/SLC7A7 | K,R,Q,H,M,L | A | Na+ | BM |
y+L | 4F2hc/y+LAT2 | SLC3A2/SLC7A6 | K,R,Q,H,M,L,A,C | A | Na+ | BM |
A | SNAT2 | SLC38A2 | G,P,A,S,C,Q,N,H | S | Na+ | AM, BM |
X−c | 4F2 hc/xCT | SLC3A2/SLC7A11 | E | A | – | AM, BM |
y+ | CAT-1 | SLC7A1 | R, K、O, H | U | – | AM, BM |
A = anti-port; AM = apical membrane; AA0 = neutral amino acids; S = symport; AA+ = cationic amino acids; BM = basolateral membrane; U = uni-port.