TABLE 2 .
MICs for each variant included in the VIM-4 cluster
| Change introduced | Variant | MIC (µg/ml) ofa: |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| AMP | AMC | PTZ | CTX | CAZ | CEP | ERT | IMI | MER | ||
| None | VIM-4 | >256 | >256 | >256 | 32 | 16 | 0.75 | 0.75 | 4 | 0.5 |
| A57S | VIM-37 | >256 | >256 | >256 | 32 | 16 | 0.75 | 0.19 | 0.5 | 0.19 |
| H224L | VIM-28 | >256 | >256 | >256 | 64 | 96 | 1.5 | 0.5 | 2 | 3 |
| R228S | VIM-1 | >256 | >256 | 48 | 24 | >256 | 6 | 0.125 | 1 | 0.25 |
| N165S | VIM-54 | >256 | >256 | >256 | 64 | >256 | 8 | 0.75 | 3 | 2 |
| N215K | VIM-19 | >256 | >256 | >256 | 32 | 32 | 1.5 | 1.5 | 4 | 0.5 |
| H252R | VIM-4H252R | >256 | >256 | >256 | 48 | 64 | 2.5 | 0.5 | 2 | 0.75 |
| Y218F | VIM-4Y218F | >256 | >256 | >256 | >256 | 24 | 0.75 | 0.75 | 4 | 1.5 |
| A57S+H224L | VIM-4A57S+H224L | >256 | >256 | 8 | 4 | 0.5 | 0.032 | 0.5 | 0.75 | 0.38 |
| A57S+R228S | VIM-27 | >256 | >256 | >256 | >256 | >256 | 12 | 1 | 8 | 8 |
| A57S+N215K | VIM-4A57S+N215K | >256 | >256 | >256 | 24 | 64 | 2 | 1.5 | 2 | 6 |
| A57S+H252R | VIM-4A57S+H252R | >256 | >256 | >256 | 6 | 1.5 | 0.064 | 0.064 | 2 | 0.5 |
| A57S+Y218F | VIM-4A57S+Y218F | >256 | >256 | 4 | 4 | 0.5 | 0.032 | 0.064 | 0.38 | 0.125 |
| H224L+R228S | VIM-26 | >256 | >256 | >256 | 32 | >256 | 4 | 0.094 | 1.5 | 0.19 |
| H224L+N215K | VIM-4H224L+N215K | >256 | >256 | >256 | >256 | >256 | 1 | 0.75 | 1.5 | 1 |
| H224L+H252R | VIM-4H224L+H252R | >256 | >256 | >256 | >256 | >256 | 2 | 3 | 3 | 2 |
| H224L+Y218F | VIM-4H224L+Y218F | 12 | 12 | 3 | 2 | 0.25 | 0.023 | 0.006 | 0.19 | 0.032 |
| R228S+N215K | VIM-4R228S+N215K | >256 | >256 | >256 | >256 | >256 | 24 | 0.25 | 1.5 | 0.75 |
| R228S+H252R | VIM-4R228S+H252R | >256 | >256 | >256 | >256 | >256 | 32 | 0.38 | 3 | 1 |
| R228S+Y218F | VIM-33 | >256 | >256 | >256 | >256 | >256 | 32 | 0.5 | 3 | 3 |
| N215K+H252R | VIM-4N215K+H252R | >256 | >256 | >256 | 64 | 24 | 2 | 0.38 | 2 | 0.75 |
| N215K+Y218F | VIM-4N215K+Y218F | >256 | >256 | >256 | >256 | 32 | 1.5 | 1 | 4 | 3 |
| H252R+Y218F | VIM-4H252R+Y218F | 24 | 64 | 4 | 2 | 0.5 | 0.023 | 0.016 | 0.38 | 0.047 |
| R228S+N215K+H252R | VIM-29 | >256 | >256 | >256 | 64 | >256 | 12 | 1 | 2 | 2 |
a
The MICs are the medians of the 3 or more values obtained or a MIC value obtained more than once. AMP, ampicillin; AMC, amoxicillin-clavulanate; PTZ, piperacillin-tazobactam; CTX, cefotaxime; CAZ, ceftazidime; CEP, cefepime; ERT, ertapenem; IMI, imipenem; MER, meropenem.