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Structural organization of a pentameric ligand-gated ion channel of the nicotinic receptor family. Data from the crystal structure of GluCl [35] illustrating the pentameric organization, the distinction between the extracellular domain ECD and the transmembrane domain TM, the orthosteric site for glutamate (in green), the Ca2+ (cyan) and ivermectin (magenta) allosteric modulatory sites respectively in ECD and TM. Reproduced from Taly et al. [36, fig. 1].
