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Recombinant mAChR in vitro binding profile. Displacement of [3H]NMS radioligand binding by increasing concentrations of (A) LSN3172176, (B) xanomeline, and (C) GSK1034702 across human recombinant mAChR subtypes M1–M5. Data points represent mean specific binding ± S.E.M. from three independent experiments each containing three replicates.
