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. 2018 Jun;365(3):602–613. doi: 10.1124/jpet.117.246454

TABLE 3.

Summary of in vitro Kd and Bmax values ± S.E.M. for [3H]LSN3172176 and [3H]NMS saturation binding to human recombinant M1–M5 mAChRs

M1 M2 M3 M4 M5
[3H]LSN3172176 Kd/nM 1.5 ± 0.3 0.6 ± 0.2 NSSB 0.8 ± 0.2 20.5 ± 11.4
Bmax 2877 ± 175 1737 ± 127 NSSB 936 ± 61.4 3813 ± 1199
[3H]NMS Kd/nM 0.209 ± 0.025 0.682 ± 0.093 0.642 ± 0.121 0.242 ± 0.026 0.464 ± 0.093
Bmax 4786 ± 128 14916 ± 568 8959 ± 466 3909 ± 97.5 7700 ± 400
% of NMS 60 12 N/A 24 50

NSSB, no significant saturable binding.