Fig. 4.

GX direct activation of GABA-A receptors in acutely dissociated neurons. GX and AP directly activated chloride currents in a concentration-dependent manner in hippocampal neurons. GX evoked significantly greater inward currents in DGGCs than CA1PCs. (A) Representative whole-cell current recordings of GX and AP in DGGCs and GX in CA1PCs. (B) Concentration-response curves for direct activation of inward currents by GX or AP alone in DGGCs and CA1PCs. Each point represents mean ± S.E.M. of data from 4 to 13 cells. *P < 0.05 vs. CA1PCs. Other derivative parameters are listed in Table 1.