Fig. 5.
GX allosteric potentiation of GABA-A receptor-mediated tonic currents and RMS channel conductance were attenuated in DGGCs from δΚΟ mice. (A) Representative whole-cell current recordings of DGGCs from WT or δΚΟ mice. Qualification of tonic current shift (between first and second gray dashed lines) was achieved relative to complete block by gabazine (GBZ) at 50 μM. (B) Concentration-response curves for allosteric activation of normalized tonic current density (pA/pF) by GX in DGGCs from WT or δΚΟ mice. *P < 0.05 vs. WT. (C) IRMS channel conductance (pA) of GX modulation in DGGCs from WT or δΚΟ mice. Each point or bar represents mean ± S.E.M. *P < 0.05 vs. GABA; #P < 0.05 vs. WT (n = 6–16 cells).